Trips to the Emirates Stadium aren't usually fun for the Toon Army.
They were spared two painful visits to this venue last season as Arsenal rolled them over in both the FA Cup and the Premier League due to lockdown but there may be no escape this time.
And the only victory for United here came in 2010 when Andy Carroll rose high to head home and win the game 1-0 in North London.
Can a new head coach change the fortunes against Mikel Arteta's side?
Lee Ryder's prediction
Arsenal were hammered 4-0 by Liverpool last weekend but don't read too much into that scoreline.
The Gunners have won six on the spin at home under Arteta and he knows that his team will be very much wounded animals after the Anfield defeat.
Newcastle have goals in them and showed it against Brentford but can they eradicate those defensive errors or will a possible change in goalkeeper make the difference?
Either way, I still expect Arsenal to keep up their good record.
I think this will be closer than it has been in a number of years but can't see past an away defeat.
Hopefully, I'm proved wrong.
Referee
Stuart Attwell (Warwickshire)
Mr Attwell is yet to brandish his red card this season.
Arsenal vs Newcastle odds with Grosvenor Sport
Arsenal 4/9
Draw 19/5
Newcastle 11/2
*odds subject to change
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