Rafa Benitez must look to find some way to cure Newcastle United's London travel sickness as they head to the Emirates as underdogs.
No team in Premier League history has lost more times in London than the Magpies.
It's just one win in two seasons in the Smoke for Newcastle since they were promoted back to the top-flight but that hasn't put Geordie fans off with the away section completely sold out.
Lee Ryder's prediction
Unai Emery mania has calmed down a little bit since the 11-game winning run for Arsenal earlier in the season.
Since then things have got a little tougher for the ex-Seville boss but the Gunners have been steady and remain in with a shout of qualifying for the Champions League and winning the Europa League.
The top four and winning one of the cups all sounds a bit like the Arsene Wenger era but nevertheless this a tough test for Benitez's team.
An in-form Manchester United side were brushed aside by the Gunners in their last Premier League outing.
Newcastle have been handed odds of 15/2 and the home win looks on the cards.
Unfortunately, it's hard to see the bookies being wrong here and a point would be a fantastic result for the Magpies.
Referee
Anthony Taylor (Wythenshawe)
The Manchester-based official sent of Arsenal's Lucas Torreira in the recent North London derby at Wembley.
Charity bet
Under 10 corners at 13/10.
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