United went into the match hot off the heels of Wednesday's incredible Champions League victory over Paris Saint-Germain, but were unable to maintain both that feel-good factor and Ole Gunnar Solskjaer's unbeaten record as United manager in the Premier League.
Instead, it was Arsenal who took the game by the scruff of the neck and a bizarre goal opened up the scoring when Granit Xhaka's long-range effort caught out David De Gea, with the United goalkeeper completely mis-reading the shot and letting in without getting close to the ball. As United pressed for an equaliser, Romelu Lukaku was guilty of missing a number of chances, before Fred was judged to have fouled Alexandre Lacazette and a penalty was awarded to the hosts, which Pierre-Emerick Aubameyang calmly tucked away to secure the victory.
Thank you for joining us for the three Premier League games today, where Liverpool beat Burnley 4-2, before Eden Hazard rescued a point for Chelsea at home to a spirited, resilient Wolves.
That all came before Arsenal beat Manchester United 2-0 to go back into the top four and cut the gap to Spurs to just a single point.
Thanks for joining us today and make sure to keep an eye out on the website for reaction to all of today's games.
Arsenal go back into the top four and make it nine home wins in a row in the league to end United's run of nine away games without defeat.
It is a first league defeat for Ole Gunnar Solskjaer and brings United crashing back down to earth after the Champions League victory against PSG in midweek.
Granit Xhaka and an Aubameyang penalty was enough to seal the win, and despite United's chances it is advantage Arsenal going itno the end of the last eight games of the season.
The gap to north London rivals Spurs was 10 points just 16 days ago, and now for Arsenal that margin has been reduced to 1 point.
Five minutes to go and Arsenal look on course to take a huge step in the direction of next season's Champions League.
The second goal has certainly taken the sting out of the United attack and the final change is made by Unai Emery, who brings off Lacazette for Eddie Nketiah.