Thomas Partey is set to miss Arsenal's game with Wolves on Sunday.
The Gunners host Nuno Espirito Santo's men in the final game before fans are allowed back into the Emirates Stadium.
But football.london understands they will once again be without their big-money summer signing due to injury.
The Ghanaian, who was signed for £45million from Atletico Madrid in the summer transfer window, came off against Villa before the international break with a thigh problem.
He missed the goalless draw with Leeds United too and now it looks like he will be out of the game against Wolves as well.
He has not yet returned to training with the first team and is unlikely to be rushed back to face Wolves as a result.
Arsenal's next game is in the Europa League against Rapid Vienna next Thursday, but with Arsenal's qualification into the last 32 already secured, it would seem unlikely that he would be risked.
The 27-year-old now faces a race against time to be fit for next weekend's huge North London Derby clash with Spurs at Tottenham Hotspur Stadium.
That is the match Arsenal and the Ghanaian are planning for him to return.
Spurs could be top of the Premier League table going into that match, giving Mikel Arteta's men added incentive to topple their fierce rivals.
