Arsenal have chosen to start Eddie Nketiah up front in place of the injured Alexandre Lacazette and the ill Pierre-Emerick Aubameyang for their Premier League clash with Everton at the Emirataes.
The England Under-21 international has been given the nod after Lacazette pulled his hamstring in the draw against Fulham, while Aubameyang is still recovering from malaria.
This means that Gabriel Martinelli doesn't start up front with the Brazilian being dropped from the starting XI entirely in place of Nicolas Pepe.
There are four more changes from Mikel Arteta for the match with Bernd Leno replacing Mat Ryan in goal again among them.
Calum Chambers and Pablo Mari come into the back four with Rob Holding captaining the Gunners for the night, after Hector Bellerin was dropped to the bench.
Thomas Partey also makes his return to the midfield in place of Mohamed Elneny, with the Gunners reverting to much of the same line up that was so successful in the victory over Slavia Prague.
Martin Odegaard makes a return to the bench after three weeks out with an ankle injury sustained on international duty with Norway.
The news on the pitch is set to be overshadowed by events outside the stadium, however.
Up to 5,000 Arsenal supporters gathered outside the Emirates stadium before the game and could still be heard in the build-up to kick-off.
They were there to demand that Stan Kroenke and KSE sell the club after the decision to sign the Gunners up to the European Super League had to be reversed following intense fan pressure.
You can follow all the action from the game with our Arsenal writers Kaya Kaynak and Chris Wheatley over on football.london's live blog.