Premier Daniel Andrews is selling his new cabinet ahead of incoming Victorian ministers being sworn in at Government House.
Mr Andrews stepped out with incoming health minister Mary-Anne Thomas and newly promoted cabinet member Sonya Kilkenny on Sunday after unveiling the frontbench he will take to the November state election.
Deputy premier and Education minister James Merlino, Health minister Martin Foley, Jobs minister Martin Pakula and Police minister Lisa Neville all resigned on Friday, prompting the reshuffle.
Ms Thomas will take over from Mr Foley as health minister - the state's fourth in as many years - while Natalie Hutchins is exchanging her corrections portfolio for education.
Five MPs will step into Labor's cabinet as it seeks a third term in office, including Ms Kilkenny, Lizzie Blandthorn, Steve Dimopoulos, Harriet Shing and speaker Colin Brooks.
Mr Brooks will become child protection and family services minister and minister for disability, ageing and carers, while Ms Blandthorn takes the planning portfolio and the role of the party's lower house leader.
Mr Dimopoulos has secured Mr Pakula's plum role of tourism, sport and major events minister as well creative industries minister, and Ms Kilkenny steps into the position of minister for corrections, youth justice, victim support and fishing and boating.
Ms Shing, a long-time parliamentary secretary, takes on the portfolios of water, regional development and equality.
Despite the mass exodus of ministers, Mr Andrews said the cabinet reshuffle demonstrated the level of talent within his government's ranks.
"The fact that we've been so swiftly able to replace them with such a talented line-up speaks to the depth of my team," he told reporters at the Frankston Hospital redevelopment site.
Other notable ministry changes included Jacinta Allan taking over as deputy premier, as well as overseeing the delivery of the 2026 Commonwealth Games, and the creation of "treaty and first peoples" portfolio, to be managed by Gabrielle Williams.
The new Andrews government ministry will be sworn in at Government House on Monday.