Anas Sarwar is calling on the Scottish Government to come up with a lockdown exit plan for Glasgow.
Scotland's biggest city is currently in Level Three restrictions, while the rest of the mainland sits at Level Two and some of the island communities in Level One.
The Scottish Labour leader says Nicola Sturgeon 's government must use "every means necessary" to get Glasgow out of its current level.
On Friday, the First Minister announced that Glasgow would remain in lockdown for at least another week due to the high number of cases in the council boundary.
No timeframe has been put on lifting restrictions in Glasgow.
Sarwar wants to see a "dramatic increase" in PCR testing in the city and walk-in jab clinics set up for anyone over 18 in hotspot areas.
Yesterday it was announced that almost half of the vaccine appointments at the SSE Hydro in Glasgow were missed over the weekend.
Of the 313 new positive cases in Scotland revealed yesterday, 155 were identified in the Greater Glasgow and Clyde area while 39 were in Lothian.
Sarwar, also a Glasgow list MSP, is calling for urgent action for his home city.
He said: "We can’t have Scotland’s largest city and one of the major economic engines of the country stuck in perpetual lockdown.
"I am calling on the government to use every means necessary to get us back on track, because to be frank the action so far has been timid, the communication has been poor and the decision-making has been inconsistent.
"The First Minister has adopted a 'wait and see' approach with businesses and families - but Glaswegians can't wait for a television press conference on a Friday afternoon to hear of their fate. We need urgent action now.
"Of course public health must come first, but so much more can be done to get the city safely out of lockdown. There needs to be a recognition that uncertainty, perpetual lockdown and economic ruin also have devastating effects on people’s health and well-being.
"That’s why Labour is calling for a dramatic increase in PCR testing and walk-in vaccination clinics for anyone aged over 18 in hotspot areas.
"There was some concern for a period that the vaccines may be less effective against the new variants. That has been refuted by new research.
"So let’s escalate the vaccine rollout and ramp/up testing in hotspot areas.
"Glasgow is at breaking point and the longer it remains locked down, the greater the impact on health and well-being and the greater the number of job losses.
"When Manchester or Liverpool found themselves kept in lockdown it was accompanied by substantial economic support for those cities.
"This is what Glasgow needs now - the money is there with millions of unallocated funds. We don’t need manufactured squabbles between Holyrood and Whitehall as an excuse for inaction.
"The public have made huge sacrifices throughout this pandemic. There has been a sense of hope and optimism in recent months. We can’t risk losing that. Let’s scale-up our response, begin to re-open and start delivering the recovery Scotland needs."
Nicola Sturgeon is set to hold a covid briefing later today as cases rise in some parts of the country.
She is expected to address the situation in Glasgow, Clackmannanshire and East Renfrewshire.
