An amber warning for 'heavy snow' has been issued for parts of Greater Manchester overnight.
Forecasters say they are expecting rain to move in during the early hours of Tuesday and turn into snow in some places.
Up to three inches of snow is likely across the area, the forecast says, with as much as six inches possible in places above 200m.
The Met Office amber warning says to expect 'some disruption during Tuesday morning'.
The snowy conditions may lead to delays on the roads, stranding some vehicles and passengers, as well as on rail travel.
"There is a good chance that some rural communities could become cut off," the Met Office says.
"Power cuts are likely and other services, such as mobile phone coverage, may be affected."
Parts of Bury, Bolton, Oldham and Rochdale are all affected by the amber warning which begins at 3am and lasts until 1pm on Tuesday.
Meanwhile, a yellow warning for ice and snow covers most of Greater Manchester.
The Arctic blast has triggered six days of weather warnings.
The Met Office forecast for tonight said: "Some snow for central and southern Scotland in the evening, whilst a band of rain in the southwest moves north, turning to snow over northern England later.
And for Tuesday: "Heavy snow for parts of northern England moving north across southern and central Scotland. Much milder to the south with rain then sunny intervals and heavy showers. Cold in north."
Simon Partridges, a Met Office forecaster, said earlier temperatures will fall as low as -6C in England overnight on Monday into Tuesday and between -10C and -15C in Scotland.
He said: "It gets a bit more interesting as we go into Tuesday and the middle of the week."
A much heavier band of rain is expected to arrive overnight on Monday and could "quickly turn to snow as it bumps up against cold air."
