Allan will play for the first time since mid-December tonight as Everton look to arrest a worrying run of home form.
The Brazilian’s inclusion in the starting line-up is one of three changes made by Carlo Ancelotti to the side that secured the historic win at Anfield over a week ago.
Dominic Calvert-Lewin is back in the starting XI while Gylfi Sigurdsson, who converted a late penalty against Liverpool, also starts.
Seamus Coleman, Tom Davies and James Rodriguez are the players to make way.
Jordan Pickford continues in goal with the Blues set to start with a back four of Mason Holgate, Michael Keane, Ben Godfrey and Lucas Digne.
Allan is in midfield with Abdoulaye Doucoure and Andre Gomes with Gylfi Sigurdsson playing in support of Richarlison and Calvert-Lewin.
EVERTON: Pickford, Holgate, Keane, Godfrey, Digne; Allan, Doucoure, Gomes; Sigurdsson, Richarlison, Calvert-Lewin.
SUBS: Virginia, King, Iwobi, Nkounkou, Bernard, Broadhead, John, Astley, Onyango.
SOUTHAMPTON: Forster, Vestergaard, Salisu, Bednarek, Bertrand, Armstrong, Ward-Prowse, Redmond, Djenepo, Ings, Adams.
SUBS: McCarthy, Stephens, Ramsey, Jankewitz, Watts, Chauke, Ferry, Tella, N’Lundalu.
