Alisson Becker, Sadio Mane and Fabinho return for Liverpool as they host Manchester City at Anfield.
The trio are part of a quartet of changes for Jurgen Klopp with Curtis Jones also coming into the side for James Milner, who drops to the bench.
New signing Ozan Kabak is also part of the substitutes, but there's no place in the squad for Ben Davies who also joined on transfer deadline day on Monday evening.
It means Jordan Henderson once more partners Fabinho at the back as the Reds aim for a first win at Anfield since December 16 when they beat Tottenham 2-1.
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Mane returns to the front line alongside Roberto Firmino and Mohamed Salah with the champions aiming to reduce the gap between the league leaders to four points.
Adrian retains his place on the bench as Caoimhin Kelleher drops out of the squad after standing in for an unwell Alisson for Wednesday night's defeat at home to Brighton.
Liverpool: Alisson; Alexander-Arnold, Fabinho, Henderson, Robertson; Wijnaldum, Thiago, Jones; Salah, Mane, Firmino.
Subs: Adrian, Milner, Oxlade-Chamberlain, Kabak, Tsimikas, Shaqiri, Origi, Phillips, N. Williams.
