Giant killers Alcoyano will face Athletic Bilbao in the last-16 of the Copa del Rey after knocking out Real Madrid on Wednesday.
The third-tier minnows stunned the 19-time Copa winners and will host the Basque side, who last weekend lifted the Spanish Super Cup after defeating Barcelona.
The other Segunda B side in the draw, Navalcarnero, will host Granada, while Osasuna will travel to second-tier Almeria.
Barca, who needed extra time to see off Segunda B Cornella on Thursday, face second-tier opposition in Rayo Vallecano.
Real Sociedad, whom Bilbao are still to face in last season's delayed final, will travel to Betis in an all-La Liga affair.
Elsewhere, Sevilla host Valencia, Girona will take on Villarreal and Valladolid host Levante.
The fixtures will take place from Jan. 26-28 and are one-off single-leg ties.
(This story refiles to add Almeria division in para 3)
(Reporting by Joseph Walker; Editing by Toby Davis)
