Liverpool make the trip to Italy knowing qualification to the next round in the Champions League is sorted and top spot is theirs too.
Surprisingly, Milan are tipped as the favourites at 21/20 with Grosvenor Sport while Liverpool are 47/20 and a draw is 29/10.
Liverpool boast a superb record in the group stage - averaging four total goals a game and yet to drop a single point. Only Ajax and Bayern Munich are the other teams who have maintained a 100% record in the group stages.
For their hosts, there is much more at stake with their European hopes hanging in the balance with Milan only ahead of Atletico Madrid on goal difference and just one point behind Porto.
A draw would not be enough for them to progress to the next stage of the Champions League but will give them a place in the Europa League. It is a must-win tie against the Reds if they want to stay in Europe's top club competition.
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Tips
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Team stats
Liverpool average four total goals per game in the Champions League while Milan average just 2.4 and only one goal per goal for the Serie A side.
In Serie A, Milan average 9.4 total corners a game while Liverpool average 10.9 total corners. In their last meeting, there were 17 corners in the tie at Anfield - over 10.5 total corners in 29/20.
Player to watch
Zlatan Ibrahimovic has always been tipped as a big-game player, so now would be a good time to prove that - especially when contract talks are under way.
The Swedish striker scored on his last appearance against Genoa and scored in the 3-0 win before finding himself on the bench against Serie A whipping boy Salernitana last weekend.
The rest on the bench points to Zlatan starting this week's Champions League showdown which, with what is at stake for the Italian club, points to him finding the net.
H2H
Despite being European heavyweights, both sides have only met three times in their entire history - with the honours spread evenly over 90 minutes with a win, draw and lose for the Reds.
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