Emergency services are currently at the scene of a road traffic collision on the A1.
Police say motorists should be advised that the A1 at Hillsborough is closed after the crash.
A PSNI spokesperson added: "Please avoid the area and seek an alternative route for your journey, if possible."
Meanwhile, in South Belfast, some traffic disruption can be expected in the Lisburn Road/ Tates Avenue/Glenmachan Street/ Boucher Road areas between 5pm and 8pm and then again between 9pm and 10.30pm this evening, due to a football match at the National Stadium.
Police are advising fans attending the match to make their way to the stadium in good time to enable staff to ensure compliance with ticketing and entry requirements and to follow the directions of marshals.
Match organisers will have no waiting cones placed near the venue to maximise public safety, minimise traffic disruption and secure emergency vehicle access to the venue and local communities.
A PSNI spokesperson added: "Motorists are asked to comply with these restrictions. If you are driving to the match, please park with consideration to the local community and businesses.
"Traffic restrictions will also be in place for a limited time after the match due to the expected volume of supporters leaving the facility."
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