The Indianapolis Colts (7-4) were dominated at home, 45-26, against the Tennessee Titans (8-3) in Week 12, giving up the top spot in the AFC South.
Without several starters on both sides of the ball and then losing left tackle Anthony Castonzo early really hurt the Colts. They were keeping pace in the first half before Castonzo’s injury but fell apart after he left and didn’t return.
Here are five takeaways from the Week 12 loss:
